Unit-III: Nuclear Magnetic Resonance Spectroscopy: 10L
Recapitulation of basic principle and general terms; equivalence and magnetic equivalence (Homotopic proton, Enantiotopic proton, Diastereotopic proton), shielding and deshielding, chemical shift, factors affecting chemical shifts, spin-spin coupling (n+1) rule, Factors affecting coupling constant; Karplus curve variation of coupling constant with dihedral angle, first order (interaction between two, three, four, and five nuclei) and non-first order spectra - classification of spin system like AX, AX2,ABX,AMX,ABC,A2B2 etc. Dynamic NMR to study hindered rotation (DMF, DMA, biphenyls, annulenes); cyclohexane ring inversion.
Unit-IV: 10L
A) Applications of NMR: Simplification of complex spectra; high field spectra, nuclear magnetic double resonance; shift reagent; solvent effect, Nuclear Overhauser Effect [NOE]. Hetero nuclear coupling in 1HNMR – deuterium exchange, Fourier transforms technique.
B) Carbon-13 NMR spectroscopy: - C-13 Nucleus, Chemical Shift and factor affecting 13C NMR, Types of 13C NMR Spectra: proton coupled (spin-spin splitting), Proton decoupled, Off resonance, DEPT, APT and NOE, Applications in organic chemistry.
- Teacher: Jagruti Barabde